解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. METHODS:Fourteen SLE patients with persistent disease activity were selected, who required prednisolone doses of >10 m...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/14397595.2018.1432331
更新日期:2018-11-01 00:00:00
abstract::Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria publish...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1467257
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:The aims of this study are to determine the incidence of congenital heart block (CHB) in the Japanese population and identify maternal factors predicting fetal CHB in anti-Ro/SSA antibody positive pregnancy. METHODS:A retrospective study was performed using 52,147 clinical records of pregnancies followed in ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1374235
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:The characteristics of lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) remain unclear. Therefore, we retrospectively analyzed the clinical characteristics of these patients in our department. METHODS:Twenty RA patients who developed LPD between April 2003 and August 2016 in ou...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1387223
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1349594
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Neutrophil extracellular traps (NETs) are peculiar structures composed of the externalized chromatin with intracellular proteins and formed by activated neutrophils in a reactive oxygen species (ROS)-dependent manner. Aberrant NETs are considered to be autoantigens for anti-neutrophil cytoplasmic antibodies (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1367116
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1438093
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate whether the level of serum matrix metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by clinical characteristics of patients in rheumatoid arthritis (RA) patients. METHODS:We analyzed data from 1087 female patients with RA. Pearson's correlation coefficie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1354431
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1333670
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS:Patients (N = 145) with active RA were randomized to placebo...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/14397595.2017.1307899
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1349573
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1 (CX3CR1)-expressing inflammatory cells. We conducted the first phase 1/2, open-label, multiple ascending dose study of E6011, a humanized anti-FKN monoclonal antibody, in Japanese rheumatoid arthritis (...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/14397595.2017.1337056
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to describe our experience with the recombinant Fab' antibody fragment against TNF-α Certolizumab Pegol (CZP) in patients with Behçet's disease (BD) refractory to standardized therapies and previous biologic agents. METHODS:Retrieved data including demographic characteri...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/14397595.2017.1285857
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS:Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Co...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1276425
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1301015
更新日期:2017-11-01 00:00:00
abstract::Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.3109/14397595.2015.1059982
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to clarify the characteristics of bony ankylosis of the facet joint of the cervical spine in rheumatoid arthritis (RA) patients who required cervical spine surgery, and its relationship to the clinical findings. METHODS:Eighty consecutive RA patients with cervical spine disorde...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1265638
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1260199
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction, and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1259603
更新日期:2017-09-01 00:00:00
abstract:AIM:The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. MATERIALS AND METHODS:Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1245176
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS:We conducted a retrospective study of 1050 individuals...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1232775
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1253813
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration and worsening of clinical symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory arthritis (NA). The associations between outcomes and clinic...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220049
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effect and potential mechanism of Cysteine-rich 61 (Cyr61) on stimulating MMP-3 expression by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. METHODS:Primarily cultured RA FLS were treated with exogenous Cyr61 protein or Cyr61-siRNA, t...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220447
更新日期:2017-05-01 00:00:00
abstract::A 61-year-old woman was admitted for long-lasting fever and recurrent opportunistic infections during the treatment of SLE. She had been diagnosed as SLE and type-IV nephritis based on a renal biopsy and serological findings. A colonoscopy and liver biopsy revealed disseminated Mycobacterium avium complex infection. H...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.997822
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1206242
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Anticentromere antibody (ACA) is generally considered to be a serological marker for systemic sclerosis (SSc). ACA-positive patients with primary Sjögren's syndrome (pSS) have also been reported. ACA often recognizes centromere proteins (CENPs): CENP-A, CENP-B, and CENP-C, and sometimes reacts to heterochrom...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1176327
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Psoriasis is a chronic autoimmune disease involving a complex network of cytokines such as interleukin (IL)-6. We tested the hypothesis that serum IL-6 level is a useful indicator of disease activity and predicts the treatment response to biologics in patients with psoriasis. METHODS:We analyzed 113 psorias...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1174328
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze clinical features and treatment outcomes of otitis media caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), i.e. otitis media with AAV (OMAAV). METHODS:This survey was performed between December 2013 and February 2014. The study began with a preliminary surv...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1177926
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170958
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:We investigated the characteristics of circulating T-helper (Th) cells and CD4+ regulatory T cells (Tregs) in polyarteritis nodosa (PAN). METHODS:Peripheral blood samples were obtained from 14 patients with PAN. Nine patients having granulomatosis with polyangiitis (GPA) and 11 healthy individuals (HC) were...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1172999
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS:A retrospective sin...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1204711
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy of tocilizumab (TCZ) monotherapy for the remission induction of microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study. METHODS:Eligible patients were aged between 20 and 80 years and were newly diagnosed with MPA according to Watts' classificat...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/14397595.2016.1160968
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to assess the effect of combination of proliferative and membranous lesions (Class III + V or IV + V) on renal outcomes as an independent category distinct from Class III and IV. METHODS:We retrospectively analyzed 103 Japanese patients (14 male and 89 female) with Class III/IV LN, w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1158896
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:The early diagnosis and treatment of rheumatoid arthritis (RA) is important to reduce joint destruction. Many of the current imaging techniques have disadvantages, such as the need for contrast agents and interpretation by specialists. Fluorescence imaging is an emerging technique that overcomes some of thes...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170946
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1153449
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To clarify the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA). METHODS:The primary endpoint of this open-labeled, prospective, observational multicenter study for secondary SS with RA was the remission rate of Simplified Disease Activity Index...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/14397595.2016.1158773
更新日期:2016-11-01 00:00:00
abstract::Spontaneous flexor tendon rupture is an unusual complication of systemic lupus erythematosus (SLE) and has not previously been reported. While tendon ruptures in association with SLE have been focused on the previous studies, upper extremity tendon ruptures are infrequently reported in the literature. Here, we present...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.924193
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:To investigate and compare the risk for malignancy in rheumatoid arthritis (RA) patients treated with biologics in Japan to the general population. METHODS:Data for 14,440 patients from 335 institutions who were given infliximab, etanercept, adalimumab, golimumab, tocilizumab, or abatacept were retrieved fr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1141740
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1117171
更新日期:2016-07-01 00:00:00